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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) greater than 27, provided that they also have problems with weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a medical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of four.1% in contrast to participants who have been given placebos) during a 12- month period, while a different study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to shed pounds can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err along the side of caution and let the FDA do its job and demand some research be done in order that the public knows the side effects and hazards of the medications before we drive them. Keep in mind that drug companies have been in business to make money and that they would say everything to keep people on the medications.

Researchers found out that participants using this drug for a year, lost weight within four weeks and have kept the body weight off throughout the 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs that are made up of more than one active ingredient, that might make them more effective and safer.

Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular could be the fact that by right now there are not any long term prescription slimming capsules that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug may also raise blood pressure levels and pulse rate, and must not be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high blood pressure levels, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients to the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.


Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant if your addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone can be used correctly, the naloxone is destroyed inside liver shortly after uptake through the intestines and has no therapeutic effect. Buprenorphine is the active substance; it is absorbed under the tongue (and throughout the mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who have had gastric bypass, in which the first section of the intestine is bypassed as well as the stomach contents empty right into a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the procedure with normal anatomy where the drug is taken up with the duodenum and transferred directly to the liver with the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be taken up by areas of the intestine which are not served from the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.